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		Meeting report Genomics through the lens of next-generation sequencing John A Capra, Lucia Carbone, Samantha J Riesenfeld, Jeffrey D Wall Genome Biology 2010, 11:306 (25 June 2010) Abstract \| Full text \| PDF \| Editor’s summary A report on the 23rd annual meeting on 'The Biology of Genomes', 11-15 May 2010, Cold Spring Harbor, USA.
		Review Escape from X inactivation in mice and humans Joel B Berletch, Fan Yang, Christine M Disteche Genome Biology 2010, 11:213 (24 June 2010) Abstract \| Full text \| PDF \| Editor’s summary Species-specific differences in X-linked genes that escape inactivation suggest a role in the evolution of sex differences.
		Research Molecular evolution of genes in avian genomes Kiwoong Nam, Carina Mugal, Benoit Nabholz, Holger Schielzeth, Jochen BW Wolf, Niclas Backstrom, Axel Kunstner, Christopher N Balakrishnan, Andreas Heger, Chris P Ponting, David F Clayton, Hans Ellegren Genome Biology 2010, 11:R68 (23 June 2010) Abstract \| Provisional PDF \| Editor’s summary Evolutionary analysis of the gene content of the chicken and zebrafinch genomes relative to other vertebrate lineages reveals avian specific patterns of evolution.
		Research The transcriptional network activated by Cln3 cyclin at the G1-to-S transition of the yeast cell cycle Francisco Ferrezuelo, Neus Colomina, Bruce Futcher, Marti Aldea Genome Biology 2010, 11:R67 (23 June 2010) Abstract \| Provisional PDF \| Editor’s summary Over-expression of CLN3 and integration with other data sets allows the elucidation of the Cln3 transcriptional network in yeast.
		Research Deficiency in mouse Y chromosome long arm gene complement is associated with sperm DNA damage Yasuhiro Yamauchi, Jonathan M Riel, Zoia Stoytcheva, Paul S Burgoyne, Monika A Ward Genome Biology 2010, 11:R66 (23 June 2010) Abstract \| Provisional PDF \| Editor’s summary Defects on the mouse Y chromosome lead to DNA damage in sperm resulting in reduced efficiency of in vitro fertilization
		Research Detection and analysis of alternative splicing in Yarrowia lipolytica reveal structural constraints facilitating nonsense-mediated decay of intron-retaining transcripts Meryem Mekouar, Isabelle Blanc-Lenfle, Christophe Ozanne, Corinne Da Silva, Corinne Cruaud, Patrick Wincker, Claude Gaillardin, Cecile Neuveglise Genome Biology 2010, 11:R65 (23 June 2010) Abstract \| Provisional PDF \| Editor’s summary Yarrowia lipolytica genes are intron rich and found to be subject to structural constraints resulting in an unusual gene structure.
		Research A mouse embryonic stem cell bank for inducible overexpression of human chromosome 21 genes Rossella De Cegli, Antonio Romito, Simona Iacobacci, Lei Mao, Mario Lauria, Anthony O Fedele, Joachim Klose, Christelle Borel, Patrick Descombes, Stylianos E Antonarakis, Diego di Bernardo, Sandro Banfi, Andrea Ballabio, Gilda Cobellis Genome Biology 2010, 11:R64 (22 June 2010) Abstract \| Provisional PDF \| PubMed \| Editor’s summary A mouse embryonic stem cell bank of inducible human chromosome 21 gene expression is shown to be an important resource for investigating trisomy.
		Research highlight MicroRNA processing without Dicer Anne Dueck, Gunter Meister Genome Biology 2010, 11:123 (21 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A microRNA essential for life is processed by Argonaute endonuclease activity.
		Research Active DNA demethylation in human postmitotic cells correlates with activating histone modifications, but not transcription levels Maja Klug, Sven Heinz, Claudia Gebhard, Lucia Schwarzfischer, Stefan W Krause, Reinhard Andreesen, Michael Rehli Genome Biology 2010, 11:R63 (18 June 2010) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Active CpG methylation is demonstrated in the differentiation of human peripheral blood monocytes and shown to correlate with histone modifications but not transcription.
		Method Whole exome capture in solution with 3Gbp of data Matthew N Bainbridge, Min Wang, Daniel L Burgess, Christie Kovar, Matthew J Rodesch, Mark D'Ascenzo, Jacob Kitzman, Yuan-Qing Wu, Irene Newsham, Todd A Richmond, Jeffrey A Jedeloh, Donna Muzny, Thomas J Albert, Richard A Gibbs Genome Biology 2010, 11:R62 (17 June 2010) Abstract \| Provisional PDF \| PubMed \| Editor’s summary A novel method for whole exome capture, using just 3Gbp of raw sequence data. Rare coding alleles can be identified in large-scale studies.
		Software Design and evaluation of genome-wide libraries for RNAi screens Thomas Horn, Thomas Sandmann, Michael Boutros Genome Biology 2010, 11:R61 (15 June 2010) Abstract \| Provisional PDF \| PubMed \| Editor’s summary NEXT-RNAi allows the design and evaluation of genome-wide RNAi screens in any organism.
		Method Global fitness profiling of fission yeast deletion strains by barcode sequencing Tian Xu Han, Xing-Ya Xu, Mei-Jun Zhang, Xu Peng, Li-Lin Du Genome Biology 2010, 11:R60 (10 June 2010) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The barcode sequences used in creating the Schizosaccharomyces pombe deletion collection are reported.
		Meeting report Genome-wide insights into eukaryotic transcriptional control James A Goodrich, Jennifer F Kugel Genome Biology 2010, 11:305 (7 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report of the Keystone Symposium on Dynamics of Eukaryotic Transcription during Development, Big Sky, Montana, USA, 7-12 April 2010.
		Correction Correction: Diatom genomes come of age Assaf Vardi, Kimberlee Thamatrakoln, Kay D Bidle, Paul G Falkowski Genome Biology 2010, 11:401 (4 June 2010) Abstract \| Full text \| PDF \| PubMed
		Research The role of transposable elements in the evolution of non-mammalian vertebrates and invertebrates Noa Sela, Eddo Kim, Gil Ast Genome Biology 2010, 11:R59 (2 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An analysis of the influence of transposable elements on non-mammalian vertebrate and invertebrate transcriptomes reveals a link between intron length and exonization.
		Research highlight Dramatic changes in transcription factor binding over evolutionary time Matthew T Weirauch, Timothy R Hughes Genome Biology 2010, 11:122 (1 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A recent study reveals a surprisingly high degree of change in the occupancy patterns of two transcription factors in the livers of five vertebrates.
		Research Composition and regulation of maternal and zygotic transcriptomes reflects species-specific reproductive mode Shai S Shen-Orr, Yitzhak Pilpel, Craig P Hunter Genome Biology 2010, 11:R58 (1 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Analysis of maternal and zygotic transcripts reveals regulatory differences between mammals and egg- laying animals.
		Research Screening the human exome: a comparison of whole genome and whole transcriptome sequencing Elizabeth T Cirulli, Abanish Singh, Kevin V Shianna, Dongliang Ge, Jason P Smith, Jessica M Maia, Erin L Heinzen, James J Goedert, David B Goldstein, Genome Biology 2010, 11:R57 (28 May 2010) Abstract \| Full text \| PDF \| Editor’s summary RNA-seq is an efficient and cheaper alternative, compared with whole genome sequencing, for identifying coding variants in humans.
		Research Evidence for natural antisense transcript-mediated inhibition of microRNA function Mohammad Ali Faghihi, Ming Zhang, Jia Huang, Farzaneh Modarresi, Marcel P Van der Brug, Michael A Nalls, Mark R Cookson, Georges St-Laurent, Claes Wahlestedt Genome Biology 2010, 11:R56 (27 May 2010) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The BACE1-antisense transcript and miR-485-5p have antagonistic regulatory effects on BACE1 transcript expression and are dysregulated in Alzheimer’s disease patients.
		Meeting report mRNA: a complex(ed) life Michaela Müller, Karla M Neugebauer, Christian Eckmann Genome Biology 2010, 11:304 (25 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report of the EMBL conference 'The Complex Life of mRNA: From Synthesis to Decay', Heidelberg, Germany, 18-21 March 2010.
		Research highlight Membrane traffic in the post-genomic era Peter Hein, Mark von Zastrow Genome Biology 2010, 11:119 (25 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A multi-parametric genetic screening approach sheds light on integrated control of the endocytic pathway in mammalian cells.
		Meeting report Sequences to systems Manolis Kellis, John L Rinn Genome Biology 2010, 11:303 (25 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report of the seventh annual meeting on Systems Biology: Global Regulation of Gene Expression, 23-27 March 2010, Cold Spring Harbor, USA.
		Research Short RNA half-lives in the slow-growing marine cyanobacterium Prochlorococcus Claudia Steglich, Debbie Lindell, Matthias Futschik, Trent Rector, Robert Steen, Sallie W Chisholm Genome Biology 2010, 11:R54 (19 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary RNA half lives in the slow growing cyanobacteria Prochlorococcus are surprisingly short and may enable rapid responses to environmental change.
		Research Towards a comprehensive structural variation map of an individual human genome Andy W Pang, Jeffrey R MacDonald, Dalila Pinto, John Wei, Muhammad A Rafiq, Donald F Conrad, Hansoo Park, Matthew E Hurles, Charles Lee, J Craig Venter, Ewen F Kirkness, Samuel Levy, Lars Feuk, Stephen W Scherer Genome Biology 2010, 11:R52 (19 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A comprehensive map of structural variation in the human genome provides a reference dataset for analyses of future personal genomes.
		Research *Studies on Xenopus laevis* intestine reveal biological pathways underlying vertebrate gut adaptation from embryo to adult** Rachel A Heimeier, Biswajit Das, Daniel R Buchholz, Maria Fiorentino, Yun-Bo Shi Genome Biology 2010, 11:R55 (19 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The developmental transcriptome of the Xenopus laevis intestine, from embryo to adult, reveals insights into the regulation of gut development in all vertebrates.

		Meeting report Genomics through the lens of next-generation sequencing John A Capra, Lucia Carbone, Samantha J Riesenfeld, Jeffrey D Wall Genome Biology 2010, 11:306 (25 June 2010) Abstract \| Full text \| PDF \| Editor’s summary A report on the 23rd annual meeting on 'The Biology of Genomes', 11-15 May 2010, Cold Spring Harbor, USA.
		Review Escape from X inactivation in mice and humans Joel B Berletch, Fan Yang, Christine M Disteche Genome Biology 2010, 11:213 (24 June 2010) Abstract \| Full text \| PDF \| Editor’s summary Species-specific differences in X-linked genes that escape inactivation suggest a role in the evolution of sex differences.
		Research Molecular evolution of genes in avian genomes Kiwoong Nam, Carina Mugal, Benoit Nabholz, Holger Schielzeth, Jochen BW Wolf, Niclas Backstrom, Axel Kunstner, Christopher N Balakrishnan, Andreas Heger, Chris P Ponting, David F Clayton, Hans Ellegren Genome Biology 2010, 11:R68 (23 June 2010) Abstract \| Provisional PDF \| Editor’s summary Evolutionary analysis of the gene content of the chicken and zebrafinch genomes relative to other vertebrate lineages reveals avian specific patterns of evolution.
		Research The transcriptional network activated by Cln3 cyclin at the G1-to-S transition of the yeast cell cycle Francisco Ferrezuelo, Neus Colomina, Bruce Futcher, Marti Aldea Genome Biology 2010, 11:R67 (23 June 2010) Abstract \| Provisional PDF \| Editor’s summary Over-expression of CLN3 and integration with other data sets allows the elucidation of the Cln3 transcriptional network in yeast.
		Research Deficiency in mouse Y chromosome long arm gene complement is associated with sperm DNA damage Yasuhiro Yamauchi, Jonathan M Riel, Zoia Stoytcheva, Paul S Burgoyne, Monika A Ward Genome Biology 2010, 11:R66 (23 June 2010) Abstract \| Provisional PDF \| Editor’s summary Defects on the mouse Y chromosome lead to DNA damage in sperm resulting in reduced efficiency of in vitro fertilization
		Research Detection and analysis of alternative splicing in Yarrowia lipolytica reveal structural constraints facilitating nonsense-mediated decay of intron-retaining transcripts Meryem Mekouar, Isabelle Blanc-Lenfle, Christophe Ozanne, Corinne Da Silva, Corinne Cruaud, Patrick Wincker, Claude Gaillardin, Cecile Neuveglise Genome Biology 2010, 11:R65 (23 June 2010) Abstract \| Provisional PDF \| Editor’s summary Yarrowia lipolytica genes are intron rich and found to be subject to structural constraints resulting in an unusual gene structure.
		Research A mouse embryonic stem cell bank for inducible overexpression of human chromosome 21 genes Rossella De Cegli, Antonio Romito, Simona Iacobacci, Lei Mao, Mario Lauria, Anthony O Fedele, Joachim Klose, Christelle Borel, Patrick Descombes, Stylianos E Antonarakis, Diego di Bernardo, Sandro Banfi, Andrea Ballabio, Gilda Cobellis Genome Biology 2010, 11:R64 (22 June 2010) Abstract \| Provisional PDF \| PubMed \| Editor’s summary A mouse embryonic stem cell bank of inducible human chromosome 21 gene expression is shown to be an important resource for investigating trisomy.
		Research highlight MicroRNA processing without Dicer Anne Dueck, Gunter Meister Genome Biology 2010, 11:123 (21 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A microRNA essential for life is processed by Argonaute endonuclease activity.
		Research Active DNA demethylation in human postmitotic cells correlates with activating histone modifications, but not transcription levels Maja Klug, Sven Heinz, Claudia Gebhard, Lucia Schwarzfischer, Stefan W Krause, Reinhard Andreesen, Michael Rehli Genome Biology 2010, 11:R63 (18 June 2010) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Active CpG methylation is demonstrated in the differentiation of human peripheral blood monocytes and shown to correlate with histone modifications but not transcription.
		Method Whole exome capture in solution with 3Gbp of data Matthew N Bainbridge, Min Wang, Daniel L Burgess, Christie Kovar, Matthew J Rodesch, Mark D'Ascenzo, Jacob Kitzman, Yuan-Qing Wu, Irene Newsham, Todd A Richmond, Jeffrey A Jedeloh, Donna Muzny, Thomas J Albert, Richard A Gibbs Genome Biology 2010, 11:R62 (17 June 2010) Abstract \| Provisional PDF \| PubMed \| Editor’s summary A novel method for whole exome capture, using just 3Gbp of raw sequence data. Rare coding alleles can be identified in large-scale studies.
		Software Design and evaluation of genome-wide libraries for RNAi screens Thomas Horn, Thomas Sandmann, Michael Boutros Genome Biology 2010, 11:R61 (15 June 2010) Abstract \| Provisional PDF \| PubMed \| Editor’s summary NEXT-RNAi allows the design and evaluation of genome-wide RNAi screens in any organism.
		Method Global fitness profiling of fission yeast deletion strains by barcode sequencing Tian Xu Han, Xing-Ya Xu, Mei-Jun Zhang, Xu Peng, Li-Lin Du Genome Biology 2010, 11:R60 (10 June 2010) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The barcode sequences used in creating the Schizosaccharomyces pombe deletion collection are reported.
		Meeting report Genome-wide insights into eukaryotic transcriptional control James A Goodrich, Jennifer F Kugel Genome Biology 2010, 11:305 (7 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report of the Keystone Symposium on Dynamics of Eukaryotic Transcription during Development, Big Sky, Montana, USA, 7-12 April 2010.
		Correction Correction: Diatom genomes come of age Assaf Vardi, Kimberlee Thamatrakoln, Kay D Bidle, Paul G Falkowski Genome Biology 2010, 11:401 (4 June 2010) Abstract \| Full text \| PDF \| PubMed
		Research The role of transposable elements in the evolution of non-mammalian vertebrates and invertebrates Noa Sela, Eddo Kim, Gil Ast Genome Biology 2010, 11:R59 (2 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An analysis of the influence of transposable elements on non-mammalian vertebrate and invertebrate transcriptomes reveals a link between intron length and exonization.
		Research highlight Dramatic changes in transcription factor binding over evolutionary time Matthew T Weirauch, Timothy R Hughes Genome Biology 2010, 11:122 (1 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A recent study reveals a surprisingly high degree of change in the occupancy patterns of two transcription factors in the livers of five vertebrates.
		Research Composition and regulation of maternal and zygotic transcriptomes reflects species-specific reproductive mode Shai S Shen-Orr, Yitzhak Pilpel, Craig P Hunter Genome Biology 2010, 11:R58 (1 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Analysis of maternal and zygotic transcripts reveals regulatory differences between mammals and egg- laying animals.
		Research Screening the human exome: a comparison of whole genome and whole transcriptome sequencing Elizabeth T Cirulli, Abanish Singh, Kevin V Shianna, Dongliang Ge, Jason P Smith, Jessica M Maia, Erin L Heinzen, James J Goedert, David B Goldstein, Genome Biology 2010, 11:R57 (28 May 2010) Abstract \| Full text \| PDF \| Editor’s summary RNA-seq is an efficient and cheaper alternative, compared with whole genome sequencing, for identifying coding variants in humans.
		Research Evidence for natural antisense transcript-mediated inhibition of microRNA function Mohammad Ali Faghihi, Ming Zhang, Jia Huang, Farzaneh Modarresi, Marcel P Van der Brug, Michael A Nalls, Mark R Cookson, Georges St-Laurent, Claes Wahlestedt Genome Biology 2010, 11:R56 (27 May 2010) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The BACE1-antisense transcript and miR-485-5p have antagonistic regulatory effects on BACE1 transcript expression and are dysregulated in Alzheimer’s disease patients.
		Meeting report mRNA: a complex(ed) life Michaela Müller, Karla M Neugebauer, Christian Eckmann Genome Biology 2010, 11:304 (25 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report of the EMBL conference 'The Complex Life of mRNA: From Synthesis to Decay', Heidelberg, Germany, 18-21 March 2010.
		Research highlight Membrane traffic in the post-genomic era Peter Hein, Mark von Zastrow Genome Biology 2010, 11:119 (25 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A multi-parametric genetic screening approach sheds light on integrated control of the endocytic pathway in mammalian cells.
		Meeting report Sequences to systems Manolis Kellis, John L Rinn Genome Biology 2010, 11:303 (25 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report of the seventh annual meeting on Systems Biology: Global Regulation of Gene Expression, 23-27 March 2010, Cold Spring Harbor, USA.
		Research Short RNA half-lives in the slow-growing marine cyanobacterium Prochlorococcus Claudia Steglich, Debbie Lindell, Matthias Futschik, Trent Rector, Robert Steen, Sallie W Chisholm Genome Biology 2010, 11:R54 (19 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary RNA half lives in the slow growing cyanobacteria Prochlorococcus are surprisingly short and may enable rapid responses to environmental change.
		Research Towards a comprehensive structural variation map of an individual human genome Andy W Pang, Jeffrey R MacDonald, Dalila Pinto, John Wei, Muhammad A Rafiq, Donald F Conrad, Hansoo Park, Matthew E Hurles, Charles Lee, J Craig Venter, Ewen F Kirkness, Samuel Levy, Lars Feuk, Stephen W Scherer Genome Biology 2010, 11:R52 (19 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A comprehensive map of structural variation in the human genome provides a reference dataset for analyses of future personal genomes.
		Research *Studies on Xenopus laevis* intestine reveal biological pathways underlying vertebrate gut adaptation from embryo to adult** Rachel A Heimeier, Biswajit Das, Daniel R Buchholz, Maria Fiorentino, Yun-Bo Shi Genome Biology 2010, 11:R55 (19 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The developmental transcriptome of the Xenopus laevis intestine, from embryo to adult, reveals insights into the regulation of gut development in all vertebrates.