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	1.	Review The case for cloud computing in genome informatics Lincoln D Stein Genome Biology 2010, 11:207 (5 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary With DNA sequencing now getting cheaper more quickly than data storage, the time may have come to use cloud computing for genome informatics.
	2.	Method Modeling non-uniformity in short-read rates in RNA-Seq data Jun Li, Hui Jiang, Wing Wong Genome Biology 2010, 11:R50 (11 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Methods for modeling read counts from short read RNA-seq data.
	3.	Research A human functional protein interaction network and its application to cancer data analysis Guanming Wu, Xin Feng, Lincoln Stein Genome Biology 2010, 11:R53 (19 May 2010) Abstract \| Provisional PDF \| PubMed \| Editor’s summary A high-quality human functional protein interaction network is constructed. Its utility is demonstrated in the identification of cancer candidate genes.
	4.	Research Evidence for natural antisense transcript-mediated inhibition of microRNA function Mohammad Ali Faghihi, Ming Zhang, Jia Huang, Farzaneh Modarresi, Marcel P Van der Brug, Michael A Nalls, Mark R Cookson, Georges St-Laurent, Claes Wahlestedt Genome Biology 2010, 11:R56 (27 May 2010) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The BACE1-antisense transcript and miR-485-5p have antagonistic regulatory effects on BACE1 transcript expression and are dysregulated in Alzheimer’s disease patients.
	5.	Meeting report Genome-wide insights into eukaryotic transcriptional control James A Goodrich, Jennifer F Kugel Genome Biology 2010, 11:305 (7 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report of the Keystone Symposium on Dynamics of Eukaryotic Transcription during Development, Big Sky, Montana, USA, 7-12 April 2010.
	6.	Research The role of transposable elements in the evolution of non-mammalian vertebrates and invertebrates Noa Sela, Eddo Kim, Gil Ast Genome Biology 2010, 11:R59 (2 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An analysis of the influence of transposable elements on non-mammalian vertebrate and invertebrate transcriptomes reveals a link between intron length and exonization.
	7.	Opinion Comparing protein abundance and mRNA expression levels on a genomic scale Dov Greenbaum, Christopher Colangelo, Kenneth Williams, Mark Gerstein Genome Biology 2003, 4:117 (29 August 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary We review the results of attempts to correlate protein abundance with mRNA expression levels, focusing on yeast.
	8.	Research Transcriptional slippage in bacteria: distribution in sequenced genomes and utilization in IS element gene expression Pavel V Baranov, Andrew W Hammer, Jiadong Zhou, Raymond F Gesteland, John F Atkins Genome Biology 2005, 6:R25 (15 February 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary To find a length of slippage-prone sequences at which selection against transcriptional slippage is evident, the transcription of repetitive runs of A and T of different lengths in 108 bacterial genomes was analyzed. IS element genes were found to exploit transcriptional slippage for regulation of gene expression.
	9.	Software DetectiV: visualization, normalization and significance testing for pathogen-detection microarray data Michael Watson, Juliet Dukes, Abu-Bakr Abu-Median, Donald P King, Paul Britton Genome Biology 2007, 8:R190 (14 September 2007) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary DetectiV is a tool for analyzing pathogen-detection microarray datasets that allows simple visualisation, normalisation and significance testing.
	10.	Comment Having an impact (factor) Gregory A Petsko Genome Biology 2008, 9:107 (29 July 2008) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A recently departed genome biologist discusses the impact factor of his life with St Peter at the Pearly Gates.
	11.	Research *Whole genome sequencing of a single Bos taurus* animal for single nucleotide polymorphism discovery** Sebastian H Eck, Anna Benet-Pagès, Krzysztof Flisikowski, Thomas Meitinger, Ruedi Fries, Tim M Strom Genome Biology 2009, 10:R82 (6 August 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The next generation sequencing of a single cow genome with low-to-medium coverage has revealed 2.44 million new SNPs.
	12.	Research highlight The amazing world of bacterial structured RNAs Eric Westhof Genome Biology 2010, 11:108 (15 March 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The discovery of several new structured non-coding RNAs in bacterial and archaeal genomes and metagenomes raises burning questions about their biological and biochemical functions.
	13.	Research Genome-wide functional analysis of human 5' untranslated region introns Can Cenik, Adnan Derti, Joseph C Mellor, Gabriel F Berriz, Frederick P Roth Genome Biology 2010, 11:R29 (11 March 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genes with short 5'UTR introns have higher expression than genes with no or long 5'UTR introns. Complex evolutionary forces act on these introns.
	14.	Editorial A decade and genome of change Clare Garvey Genome Biology 2010, 11:120 (5 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Innovations in genomic technologies have generated huge advances in biomedical research over the last decade.
	15.	Review The origin and early evolution of eukaryotes in the light of phylogenomics Eugene V Koonin Genome Biology 2010, 11:209 (5 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Comparative genomics and new phylogenies of eukaryote groups suggest a scenario in which the mitochondrial endosymbiosis triggered the origin of eukaryotes.
	16.	Meeting report Sequences to systems Manolis Kellis, John L Rinn Genome Biology 2010, 11:303 (25 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report of the seventh annual meeting on Systems Biology: Global Regulation of Gene Expression, 23-27 March 2010, Cold Spring Harbor, USA.
	17.	Research The dissection of transcriptional modules regulated by various drugs of abuse in the mouse striatum Marcin Piechota, Michal Korostynski, Wojciech Solecki, Agnieszka Gieryk, Michal Slezak, Wiktor Bilecki, Barbara Ziolkowska, Elzbieta Kostrzewa, Iwona Cymerman, Lukasz Swiech, Jacek Jaworski, Ryszard Przewlocki Genome Biology 2010, 11:R48 (4 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The transcriptional response to six commonly-abused drugs was assessed in the mouse brain revealing common modules of drug-induced genes.
	18.	Research Widespread remodeling of mid-coding sequence nucleosomes by Isw1 Itay Tirosh, Nadejda Sigal, Naama Barkai Genome Biology 2010, 11:R49 (10 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In yeast, the chromatin remodeler Isw1 shifts nucleosomes from mid-coding, to more 5’ regions of genes and may regulate transcriptional elongation.
	19.	Research Nucleosome rotational setting is associated with transcriptional regulation in promoters of tissue-specific human genes Charles Hebert, Hugues Roest Crollius Genome Biology 2010, 11:R51 (12 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Human genes contain a 10 bp repeat of RR dinucleotides focused around the first nucleosome position suggesting a role in transcriptional control.
	20.	Research Towards a comprehensive structural variation map of an individual human genome Andy W Pang, Jeffrey R MacDonald, Dalila Pinto, John Wei, Muhammad A Rafiq, Donald F Conrad, Hansoo Park, Matthew E Hurles, Charles Lee, J Craig Venter, Ewen F Kirkness, Samuel Levy, Lars Feuk, Stephen W Scherer Genome Biology 2010, 11:R52 (19 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A comprehensive map of structural variation in the human genome provides a reference dataset for analyses of future personal genomes.
	21.	Research Short RNA half-lives in the slow-growing marine cyanobacterium Prochlorococcus Claudia Steglich, Debbie Lindell, Matthias Futschik, Trent Rector, Robert Steen, Sallie W Chisholm Genome Biology 2010, 11:R54 (19 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary RNA half lives in the slow growing cyanobacteria Prochlorococcus are surprisingly short and may enable rapid responses to environmental change.
	22.	Research Screening the human exome: a comparison of whole genome and whole transcriptome sequencing Elizabeth T Cirulli, Abanish Singh, Kevin V Shianna, Dongliang Ge, Jason P Smith, Jessica M Maia, Erin L Heinzen, James J Goedert, David B Goldstein, Genome Biology 2010, 11:R57 (28 May 2010) Abstract \| Full text \| PDF \| Editor’s summary RNA-seq is an efficient and cheaper alternative, compared with whole genome sequencing, for identifying coding variants in humans.
	23.	Research highlight Dramatic changes in transcription factor binding over evolutionary time Matthew T Weirauch, Timothy R Hughes Genome Biology 2010, 11:122 (1 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A recent study reveals a surprisingly high degree of change in the occupancy patterns of two transcription factors in the livers of five vertebrates.
	24.	Research A mouse embryonic stem cell bank for inducible overexpression of human chromosome 21 genes Rossella De Cegli, Antonio Romito, Simona Iacobacci, Lei Mao, Mario Lauria, Anthony O Fedele, Joachim Klose, Christelle Borel, Patrick Descombes, Stylianos E Antonarakis, Diego di Bernardo, Sandro Banfi, Andrea Ballabio, Gilda Cobellis Genome Biology 2010, 11:R64 (22 June 2010) Abstract \| Provisional PDF \| PubMed \| Editor’s summary A mouse embryonic stem cell bank of inducible human chromosome 21 gene expression is shown to be an important resource for investigating trisomy.