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	1. 5442 Accesses	Research Screening the human exome: a comparison of whole genome and whole transcriptome sequencing Elizabeth T Cirulli, Abanish Singh, Kevin V Shianna, Dongliang Ge, Jason P Smith, Jessica M Maia, Erin L Heinzen, James J Goedert, David B Goldstein, Genome Biology 2010, 11:R57 (28 May 2010) Abstract \| Full text \| PDF \| Editor’s summary RNA-seq is an efficient and cheaper alternative, compared with whole genome sequencing, for identifying coding variants in humans.
	2. 2570 Accesses	Review The case for cloud computing in genome informatics Lincoln D Stein Genome Biology 2010, 11:207 (5 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary With DNA sequencing now getting cheaper more quickly than data storage, the time may have come to use cloud computing for genome informatics.
	3. 2538 Accesses	Research A human functional protein interaction network and its application to cancer data analysis Guanming Wu, Xin Feng, Lincoln Stein Genome Biology 2010, 11:R53 (19 May 2010) Abstract \| Provisional PDF \| PubMed \| Editor’s summary A high-quality human functional protein interaction network is constructed. Its utility is demonstrated in the identification of cancer candidate genes.
	4. 2450 Accesses	Research Evidence for natural antisense transcript-mediated inhibition of microRNA function Mohammad Ali Faghihi, Ming Zhang, Jia Huang, Farzaneh Modarresi, Marcel P Van der Brug, Michael A Nalls, Mark R Cookson, Georges St-Laurent, Claes Wahlestedt Genome Biology 2010, 11:R56 (27 May 2010) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The BACE1-antisense transcript and miR-485-5p have antagonistic regulatory effects on BACE1 transcript expression and are dysregulated in Alzheimer’s disease patients.
	5. 2177 Accesses	Research Towards a comprehensive structural variation map of an individual human genome Andy W Pang, Jeffrey R MacDonald, Dalila Pinto, John Wei, Muhammad A Rafiq, Donald F Conrad, Hansoo Park, Matthew E Hurles, Charles Lee, J Craig Venter, Ewen F Kirkness, Samuel Levy, Lars Feuk, Stephen W Scherer Genome Biology 2010, 11:R52 (19 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A comprehensive map of structural variation in the human genome provides a reference dataset for analyses of future personal genomes.
	6. 1981 Accesses	Research The role of transposable elements in the evolution of non-mammalian vertebrates and invertebrates Noa Sela, Eddo Kim, Gil Ast Genome Biology 2010, 11:R59 (2 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An analysis of the influence of transposable elements on non-mammalian vertebrate and invertebrate transcriptomes reveals a link between intron length and exonization.
	7. 1903 Accesses	Software Ultrafast and memory-efficient alignment of short DNA sequences to the human genome Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg Genome Biology 2009, 10:R25 (4 March 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Bowtie: a new ultrafast memory-efficient tool for the alignment of short DNA sequence reads to large genomes.
	8. 1884 Accesses	Review Between a chicken and a grape: estimating the number of human genes Mihaela Pertea, Steven L Salzberg Genome Biology 2010, 11:206 (5 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The number of genes in the human genome is still an estimate.
	9. 1828 Accesses	Method Modeling non-uniformity in short-read rates in RNA-Seq data Jun Li, Hui Jiang, Wing Wong Genome Biology 2010, 11:R50 (11 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Methods for modeling read counts from short read RNA-seq data.
	10. 1825 Accesses	Research Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman Genome Biology 2002, 3:research0034 (18 June 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Using real-time reverse transcription PCR ten housekeeping genes from different abundance and functional classes in various human tissues were evaluated. The conventional use of a single gene for normalization leads to relatively large errors in a significant proportion of samples tested.
	11. 1600 Accesses	Meeting report mRNA: a complex(ed) life Michaela Müller, Karla M Neugebauer, Christian Eckmann Genome Biology 2010, 11:304 (25 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report of the EMBL conference 'The Complex Life of mRNA: From Synthesis to Decay', Heidelberg, Germany, 18-21 March 2010.
	12. 1497 Accesses	Method Whole exome capture in solution with 3Gbp of data Matthew N Bainbridge, Min Wang, Daniel L Burgess, Christie Kovar, Matthew J Rodesch, Mark D'Ascenzo, Jacob Kitzman, Yuan-Qing Wu, Irene Newsham, Todd A Richmond, Jeffrey A Jedeloh, Donna Muzny, Thomas J Albert, Richard A Gibbs Genome Biology 2010, 11:R62 (17 June 2010) Abstract \| Provisional PDF \| PubMed \| Editor’s summary A novel method for whole exome capture, using just 3Gbp of raw sequence data. Rare coding alleles can be identified in large-scale studies.
	13. 1461 Accesses	Review Cancer genomics identifies determinants of tumor biology Elaine R Mardis Genome Biology 2010, 11:211 (5 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Whole-genome analysis of human tumors has identified some unsuspected tumor-associated genes
	14. 1445 Accesses	Review The origin and early evolution of eukaryotes in the light of phylogenomics Eugene V Koonin Genome Biology 2010, 11:209 (5 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Comparative genomics and new phylogenies of eukaryote groups suggest a scenario in which the mitochondrial endosymbiosis triggered the origin of eukaryotes.
	15. 1430 Accesses	Research highlight Dramatic changes in transcription factor binding over evolutionary time Matthew T Weirauch, Timothy R Hughes Genome Biology 2010, 11:122 (1 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A recent study reveals a surprisingly high degree of change in the occupancy patterns of two transcription factors in the livers of five vertebrates.
	16. 1418 Accesses	Meeting report Genome-wide insights into eukaryotic transcriptional control James A Goodrich, Jennifer F Kugel Genome Biology 2010, 11:305 (7 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report of the Keystone Symposium on Dynamics of Eukaryotic Transcription during Development, Big Sky, Montana, USA, 7-12 April 2010.
	17. 1258 Accesses	Research Evaluation of next generation sequencing platforms for population targeted sequencing studies Olivier Harismendy, Pauline C Ng, Robert L Strausberg, Xiaoyun Wang, Timothy B Stockwell, Karen Y Beeson, Nicholas J Schork, Sarah S Murray, Eric J Topol, Samuel Levy, Kelly A Frazer Genome Biology 2009, 10:R32 (27 March 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Human sequence generated from three next-generation sequencing platforms reveals systematic variability in sequence coverage due to local sequence characteristics.
	18. 1226 Accesses	Editorial A decade and genome of change Clare Garvey Genome Biology 2010, 11:120 (5 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Innovations in genomic technologies have generated huge advances in biomedical research over the last decade.
	19. 1216 Accesses	Method A scaling normalization method for differential expression analysis of RNA-seq data Mark D Robinson, Alicia Oshlack Genome Biology 2010, 11:R25 (2 March 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A novel and empirical method for normalization of RNA-seq data is presented
	20. 1134 Accesses	Method Global fitness profiling of fission yeast deletion strains by barcode sequencing Tian Xu Han, Xing-Ya Xu, Mei-Jun Zhang, Xu Peng, Li-Lin Du Genome Biology 2010, 11:R60 (10 June 2010) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The barcode sequences used in creating the Schizosaccharomyces pombe deletion collection are reported.
	21. 1092 Accesses	Review Direct sequencing of the human microbiome readily reveals community differences Justin Kuczynski, Elizabeth K Costello, Diana R Nemergut, Jesse Zaneveld, Christian L Lauber, Dan Knights, Omry Koren, Noah Fierer, Scott T Kelley, Ruth E Ley, Jeffrey I Gordon, Rob Knight Genome Biology 2010, 11:210 (5 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Future sequencing of the human microbiota will require greater breadth rather than depth.
	22. 1062 Accesses	Comment And they said it wouldn't last... Gregory A Petsko Genome Biology 2010, 11:121 (5 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In the 10 years that Genome Biology has been published the scientific changes have been amazing, as have the changes in the culture of science.
	23. 1030 Accesses	Software CellProfiler: image analysis software for identifying and quantifying cell phenotypes Anne E Carpenter, Thouis R Jones, Michael R Lamprecht, Colin Clarke, In Kang, Ola Friman, David A Guertin, Joo Chang, Robert A Lindquist, Jason Moffat, Polina Golland, David M Sabatini Genome Biology 2006, 7:R100 (31 October 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary CellProfiler, the first free, open-source system for flexible and high-throughput cell image analysis is described.
	24. 981 Accesses	Review The next frontier of systems biology: higher-order and interspecies interactions Michael A Fischbach, Nevan J Krogan Genome Biology 2010, 11:208 (5 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Systems biology is set to go beyond single species to the study of interspecies interactions.
	25. 971 Accesses	Research highlight MicroRNA processing without Dicer Anne Dueck, Gunter Meister Genome Biology 2010, 11:123 (21 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A microRNA essential for life is processed by Argonaute endonuclease activity.